Hormone pellet therapy offers a consistent, time-released method of supporting hormone levels using small pellets placed just beneath the skin. These pellets are designed to dissolve slowly over several months, gradually releasing hormones over time without requiring daily administration.
EvexiPEL pellet therapy is tailored to individual needs, allowing us to customize dosing based on symptoms, lab results, and long-term wellness goals. The expected treatment interval is determined individually, and hormone levels, response, and duration can vary.


Hormone pellet therapy may support:
Many patients choose pellet therapy for its steady, reliable hormone delivery.
Hormone pellet therapy may be considered for:
Steady, long-lasting hormone delivery may help support more consistent energy through the day.
Hormone levels shift with age, and pellets are designed to reduce the swings that can affect emotional steadiness.
May help reduce hot flashes, night sweats, and sleep disturbances.
May support metabolic function affected by hormonal decline.
May support hormone levels that influence desire and comfort.
Some patients report difficulty concentrating alongside other hormonal symptoms. Hormone evaluation can help identify whether levels are a contributing factor.
Pellet therapy involves placing a small, customized hormone pellet under the skin, typically in the hip or upper buttock area. Once inserted, the pellet gradually dissolves, releasing consistent levels of hormones into the bloodstream over time.
The pellet releases hormones over time and does not require daily dosing. Individual absorption, hormone levels, symptom response, and duration of effect can vary. If pellet therapy is considered appropriate, the provider will select a dose based on the clinical evaluation, relevant laboratory findings, medical history, and treatment goals.
Before starting pellet therapy, it helps to understand how it differs from creams, pills, or patches.

Hormone pellet placement is a minimally invasive procedure performed in the office after clinical evaluation and informed consent.
We review your symptoms, medical history, and wellness goals to determine the best course of action.
Hormone evaluation may be recommended to guide dosing and treatment planning.
A small numbing injection is applied, followed by placement of the pellet through a tiny incision.
A small bandage is placed over the site. Mild soreness may occur for a few days.
We monitor your response and plan your next insertion accordingly.
Response to hormone pellet therapy varies according to the hormone prescribed, dose, absorption, symptoms being treated, and individual health factors. Some patients may notice changes within several weeks, while others may not experience the intended improvement.
The practice will monitor symptoms, possible adverse effects, and laboratory findings when appropriate. Because a pellet cannot be readily adjusted after insertion, patients should contact the practice if they experience concerning or unexpected symptoms.

Pellet therapy may suit adults who have:
We will review your symptoms, medical history, medications, relevant laboratory findings, treatment goals, and available alternatives to determine whether the potential benefits of pellet therapy outweigh the risks in your situation.
Our approach to hormone pellet therapy is built around careful dosing and consistent follow-up.

Our wellness program blends multiple integrative therapies, which may include:

Most pellets last three to six months, depending on your dosage and how quickly your body absorbs them.
Not easily. Once a pellet is placed, it continues releasing hormone until it dissolves, and removal would require reopening the insertion site. This is why dosing is approached conservatively and why your history and labs are reviewed carefully first.
Temporary soreness, bruising, or swelling at the insertion site is common. Hormone-related effects can include breast tenderness, acne or oily skin, fluid retention, or increased hair growth, depending on the hormone and dose. Infection or pellet extrusion is uncommon but possible.
Most patients feel only mild pressure, since the area is numbed first. Any discomfort typically resolves quickly.
Follow the aftercare instructions provided by the practice. You may be advised to limit strenuous lower-body exercise and avoid soaking the insertion site for a specified period while it heals.
Hormone testing is often recommended to determine appropriate dosing and to establish a baseline for follow-up.
Coverage varies by insurance plan, treatment, and pharmacy arrangement. Contact your insurer and the practice to confirm expected costs. Financing through M Lend Financial may be available for eligible services, subject to terms and approval.
Connect with Sikora Integrative Medicine to review your symptoms, discuss Evexipel pellet therapy, and receive personalized guidance based on your hormone needs and goals. Financing through M Lend Financial may be available for eligible services, subject to terms and approval.
Disclaimer: This information is provided for educational purposes only and is not intended to be medical advice. It should not be used to diagnose, treat, or cure any condition. Always consult your healthcare provider for personalized guidance. Services are available exclusively to Florida residents.
© 2026 Sikora Integrative Medicine. All Rights Reserved.
© 2026 Sikora Integrative Medicine.
All Rights Reserved.